N7261
Sigma

Nortriptyline hydrochloride

≥98% (TLC), powder

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Molecular Formula

C₁₉H₂₁N � HCl

Molecular Weight

299.84

CAS Number

894-71-3

MDL number

MFCD00058024

PubChem Substance ID

24278107

EG/EC Number

212-973-0

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Descriptions

Features and Benefits

The powder is stable at least 5 years at room temperature.

Biochem/physiol Actions

Tricyclic antidepressant that is a more potent inhibitor of the norepinephrine transporter (K_i = 3.4 nM) than the serotonin transporter (K_i = 161 nM). 5-HT₂ serotonin receptor antagonist.

Properties

assay

≥98% (TLC)

form

powder

color

white to off-white

solubility

ethanol: 100 mg/mL

H₂O: soluble

Gene Information

human ... HTR2A(3356), HTR2B(3357), HTR2C(3358)

References

Reference

Sanchez, C., and Hyttel, J., Comparison of the effects of antidepressants and their metabolites on reuptake of biogenic amines and on receptor binding. Cell. Mol. Neurobiol. 19, 467, (1999) abstract

Nakashita, M., et al., Effects of tricyclic and tetracyclic antidepressants on the three subtypes of GABA transporter. J. Neurosci. Res. 29, 87-91, (1997)

Torres, G.E., et al., Plasma membrane monoamine transporters: structure, regulation and function. Nat. Rev. Neurosci. 4, 13-25, (2003) abstract

Kleven, M.S., and Koek, W., Discriminative stimulus properties of cocaine: enhancement by monoamine reuptake blockers. J. Pharmacol. Exp. Ther. 284, 1015-1025, (1998) abstract

Safety

Hazard Codes

Risk Statements

Safety Statements

22-36

WGK Germany

RTECS

HP0175000