N7634
Sigma

Nifedipine

≥98% (TLC), powder

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Synonym

1,4-Dihydro-2,6-dimethyl-4-(2-nitrophenyl)-3,5-pyridinedicarboxylic acid dimethyl ester

Molecular Formula

C₁₇H₁₈N₂O₆

Molecular Weight

346.33

CAS Number

21829-25-4

MDL number

MFCD00057326

PubChem Substance ID

24277855

EG/EC Number

244-598-3

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Descriptions

Biochem/physiol Actions

L-type Ca²⁺ channel blocker; induces apoptosis in human glioblastoma cells.

Properties

assay

≥98% (TLC)

form

powder

color

yellow

solubility

DMSO: soluble

ethanol: soluble

Gene Information

human ... ADORA2A(135), ADORA3(140), CACNA2D1(781), CYP1A2(1544), KCNH1(3756), TTR(7276)

mouse ... Cacna1c(12288)

rat ... Adora1(29290), Adora2a(25369), Cacna1c(24239), Cacna1d(29716), Kcnj1(24521), Kcnn4(65206), Tbxas1(24886)

storage temp.

2-8°C

References

Reference

Segawa, D., et al., Cardiac inotropic vs. chronotropic selectivity of isradipine, nifedipine, and clevidipine, a new ultrashort-acting dihydropyridine. Eur. J. Pharmacol. 380, 123-128, (1999) abstract

Eliot, L.A., and Jamali, F., Pharmacokinetics and pharmacodynamics of nifedipine in untreated and atorvastatin-treated hyperlipidemic rats. J. Pharmacol. Exp. Ther. 291, 188-193, (1999) abstract

Zangar, R.C., et al., Effect of calcium channel antagonists nifedipine and nicardipine on rat cytochrome P-450 2B and 3A forms. J. Pharmacol. Exp. Ther. 290, 1436-1441, (1999) abstract

Safety

Hazard Codes

Risk Statements

Safety Statements

26-36

WGK Germany

RTECS

US7975000