N7768
Sigma

[Leu³¹, Pro³⁴]-Neuropeptide Y porcine

≥97% (HPLC)

Synonym

[Leu³¹, Pro³⁴]-NPY

Amino Acid Sequence

Tyr-Pro-Ser-Lys-Pro-Asp-Asn-Pro-Gly-Glu-Asp-Ala-Pro-Ala-Glu-Asp-Leu-Ala-Arg-Tyr-Tyr-Ser-Ala-Leu-Arg-His-Tyr-Ile-Asn-Leu-Leu-Thr-Arg-Pro-Arg-Tyr-NH₂

Molecular Formula

C₁₉₀H₂₈₆N₅₄O₅₆

Molecular Weight

4222.63

CAS Number

125580-28-1

MDL number

MFCD00166234

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Descriptions

Biochem/physiol Actions

Selective neuropeptide Y₁ and Y₅ receptor agonist.

Properties

assay

≥97% (HPLC)

Gene Information

pig ... NPY(397304)

storage temp.

−20°C

References

Reference

Serone, A.P., et al., Role of NPY Y₁ receptors in cardiovascular control in the conscious rabbit. J. Cardiovasc. Pharmacol. 35, 315, (2000) abstract

Dumont, Y., et al., Species differences in the expression and distribution of the neuropeptide Y Y₁, Y₂, Y₄, and Y₅ receptors in rodents, guinea pig, and primates brains. J. Comp. Neurol. 402, 372, (1998) abstract

Raposinho, P.D., Evidence that the inhibition of luteinizing hormone secretion exerted by central administration of neuropeptide Y (NPY) in the rat is predominantly mediated by the NPY-Y₅ receptor subtype. Endocrinology 140, 4046, (1999) abstract

Safety

WGK Germany