N8768
Sigma

Natriuretic Peptide, C-Type

≥95% (HPLC)

Synonym

CNP

Amino Acid Sequence

Gly-Leu-Ser-Lys-Gly-Cys-Phe-Gly-Leu-Lys-Leu-Asp-Arg-Ile-Gly-Ser-Met-Ser-Gly-Leu-Gly-Cys [Disulfide Bridge: 6-22]

Molecular Formula

C₉₃H₁₅₇N₂₇O₂₈S₃

Molecular Weight

2197.60

CAS Number

127869-51-6

MDL number

MFCD00080348

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Descriptions

Biochem/physiol Actions

C-type natriuretic peptide is produced in the hypothalamus, anterior pituitary, and most major endocrine glands. It has potent venodilatory and coronary vasodilatory effects, but minimal effects on renal function.

Properties

assay

≥95% (HPLC)

composition

Peptide content, ≥65%

Gene Information

human ... NPPC(4880)

storage temp.

−20°C

References

Reference

Fowkes, R.C., and McArdle, C.A., C-type natriuretic peptide: an important neuroendocrine regulator?. Trends Endocrinol. Metab. 11, 333, (2000) abstract

Chen, H.H., and Burnett, J.C., Jr., C-type natriuretic peptide: the endothelial component of the natriuretic peptide system. J. Cardiovasc. Pharmacol. 32, S22-S28, (1998) abstract

Takei, Y., Structural and functional evolution of the natriuretic peptide system in vertebrates. Int. Rev. Cytol. 194, 1-66, (2000) abstract

Safety

WGK Germany