O3636
Sigma

1H-[1,2,4]Oxadiazolo[4,3-a]quinoxalin-1-one

powder

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1 of 1

Synonym

ODQ

Molecular Formula

C₉H₅N₃O₂

Molecular Weight

187.15

CAS Number

41443-28-1

MDL number

MFCD00792620

PubChem Substance ID

24278054

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Descriptions

Biochem/physiol Actions

Selective inhibitor of nitric oxide-sensitive guanylyl cyclase.

Caution

Hygroscopic

Properties

form

powder

color

pale yellow

solubility

ethanol: 1.2 mg/mL

DMSO: 5 mg/mL

H₂O: insoluble

Gene Information

human ... NOS1(4842), NOS2A(4843), NOS2B(201288), NOS2C(645740), NOS3(4846)

storage temp.

2-8°C

References

Reference

Schrammel, et al., Characterization of 1H [1,2,4]oxadiazolo[4,3a]quinoxalin1one as a heme-site inhibitor of nitric oxide-sensitive guanylyl cyclase. Mol. Pharmacol. 50, 1-5, (1996) abstract

Brunner, et al., Novel guanylyl cyclase inhibitor ODQ reveals role of nitric oxidebut not of cyclic-GMP in endothelin-1 secretion. FEBS Lett. 376, 262-266, (1995) abstract

Garthwaite, et al., Potent and selective inhibition of nitric oxidesensitive guanylyl cyclase by 1H[1,2,4]oxadiazolo[4,3a]quinoxalin-1-one. Mol. Pharmacol. 48, 184-188, (1995) abstract

Safety

Hazard Codes

Risk Statements

36/37/38

Safety Statements

26-36

WGK Germany