O6754
Sigma

1-Oleoyl-2-acetyl-sn-glycerol

~98% (TLC), oil

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Synonym

1-(cis-9-Octadecenoyl)-2-acetyl-sn-glycerol

2-Acetyl-1-oleoyl-sn-glycerol

OAG

Molecular Formula

C₂₃H₄₂O₅

Molecular Weight

398.58

CAS Number

86390-77-4

Beilstein Registry Number

8168731

MDL number

MFCD00166985

PubChem Substance ID

24898039

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Descriptions

Biochem/physiol Actions

Often used as an activator of calcium-dependent protein kinase C (PKC).

Caution

Some isomerization may occur during storage or in solution.

Other Notes

Synthetic, cell permeable diacylglycerol analog.

Properties

assay

~98% (TLC)

form

oil

total impurities

1,3-isomer, trace

color

yellow

solubility

ethanol: 20 mg/mL

DMSO: soluble

Gene Information

human ... PRKCA(5578)

shipped in

dry ice

storage temp.

−20°C

References

Reference

Wang, R., et al., Protein kinase C regulates Fas (CD95/APO-1) expression. J. Immunol. 161, 2201-2207, (1998) abstract

Saito, Y., et al., Activation of protein kinase C alpha enhances human growth hormone-binding protein release. Mol. Cell. Endocrinol. 146, 197-205, (1998) abstract

Kosaka, C., et al., Cell cycle arrest in the G2 phase induced by phorbol ester and diacylglycerol in vascular endothelial cells. Am. J. Physiol. 270(1 Pt 1), C170-C178, (1996)

Barber, L.A., Vasko, M.R., Activation of protein kinase C augments peptide release from rat sensory neurons. J. Neurochem. 67, 72, (1996) abstract

Kim, Y.C., et al., Protein kinase C mediates the desensitization of CCh-activated nonselective cationic current in guinea-pig gastric myocytes. Pflugers Arch. 436, 1, (1998) abstract

Safety

WGK Germany

10-23

Related Categories

... Lipids in Cell Signaling > Diacylglycerols

... Neutral Glycerides > Diradylglycerols

MSDS

Certificate of Analysis

Certificate of Origin

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