P0878
Sigma

O-Phospho-L-serine

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Synonym

L-2-Amino-3-hydroxypropanoic acid 3-phosphate

L-Serine O-phosphate

L-SOP

Molecular Formula

(HO)₂P(O)OCH₂CH(NH₂)CO₂H

Molecular Weight

185.07

CAS Number

407-41-0

Beilstein Registry Number

1726826

MDL number

MFCD00065935

PubChem Substance ID

24277998

EG/EC Number

206-986-0

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Descriptions

Biochem/physiol Actions

Group III metabotropic glutamate receptor agonist (mGluR₄, mGluR₇, and mGluR₈).

Packaging

10 mg in autosmp vl

Properties

190 °C(lit.)

Gene Information

human ... GRM4(2914), GRM7(2917), GRM8(2918)

References

Reference

Turner, et al., Group III metabotropic glutamate receptors control corticothalamic synaptic transmission in the rat thalamus in vitro. J. Physiol. London, England 519, 481-491, (1999) abstract

Klunk, et al., L-Phosphoserine, a metabolite elevated in Alzheimer's disease, interacts with specific L-gluamate receptor subtypes. J. Neurochem. 56, 1997, (1991) abstract

Klunk, et al., Possible roles of L-phosphoserine in the pathogenesis of Alzheimer's disease. Mol. Chem. Neurophathol. 15, 51-73, (1991)

Merck

Merck 13,7449

Beilstein

Beil. 4,IV,3120

Safety

WGK Germany