P1269
Sigma

Phorbol 12,13-dibutyrate

≥98% (TLC), powder

zoom

1 of 1

Synonym

PDBu

Molecular Formula

C₂₈H₄₀O₈

Molecular Weight

504.61

CAS Number

37558-16-0

Beilstein Registry Number

6551234

MDL number

MFCD00036783

PubChem Substance ID

24898178

Expand/Collapse All

Descriptions

Biochem/physiol Actions

Tumor promoting phorbol ester that activates protein kinase C and promotes nitric oxide production.

Caution

Photosensitive

Features and Benefits

Less hydrophobic then PMA, making it easier to wash out of cells in tissue culture.

Reconstitution

Stock solution cannot be made in aqueous media; dissolve in a water-miscible organic solvent before dilution to working concentrations in aqueous media.

Properties

assay

≥98% (TLC)

form

powder

color

clear, light yellow, film

solubility

H₂O: 30 μM

DMSO: soluble

acetone: soluble

ethanol: soluble

Gene Information

mouse ... Prkcd(18753)

storage temp.

−20°C

References

Reference

Yanagita, et al., Protein kinase C and the opposite regulation of sodium channel α- and β1-subunit mRNA levels in adrenal chromaffin cells. J. Neurochem. 73, 1749-1757, (1999) abstract

Irie, K., et al., Establishment of a binding assay for protein kinase C isozymes using synthetic C1 peptides and development of new medicinal leads with protein kinase C isozyme and C1 domain selectivity. Pharmacol. Ther. 93, 271-281, (2002) abstract

Hori, et al., Presynaptic mechanism for phorbol ester-induced synaptic potentiation. J. Neurosci. 19, 7262-7267, (1999) abstract

Shindo, M., et al., Synthesis and phorbol ester binding of the cysteine-rich domains of diacylglycerol kinase (DGK) isozymes. DGKγ and DGKβ are new targets of tumor-promoting phorbol esters. J. Biol. Chem. 278, 18448-18454, (2003) abstract

Safety

Hazard Codes

Risk Statements

36/37/38

Safety Statements

26-36

WGK Germany

RTECS

EK7767000

8-10