P186
Sigma

PD 123,319 di(trifluoroacetate) salt hydrate

powder, ≥98% (HPLC)

1 of 1

Synonym

S-(+)-1-[(4-(Dimethylamino)-3-methylphenyl)methyl]-5-(diphenylacetyl)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine-6-carboxylic acid di(trifluoroacetate) salt hydrate

Molecular Formula

C₃₁H₃₂N₄O₃ · 2C₂HF₃O₂ · xH₂O

Molecular Weight

736.66 (anhydrous basis)

CAS Number

136676-91-0

PubChem Substance ID

24898250

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Descriptions

Biochem/physiol Actions

Potent and selective non-peptide AT₂ angiotensin II receptor antagonist.

Caution

Hygroscopic

Legal Information

Sold with permission of Warner-Lambert Company.

Properties

assay

≥98% (HPLC)

form

powder

optical activity

[α]22/D +8.6°, c = 0.87 in methanol(lit.)

storage condition

desiccated

solubility

H₂O: 12 mg/mL

storage temp.

2-8°C

References

Reference

Widdop, et al., Differential blockade of central effects of angiotensin II by AT₂-receptor antagonists. Am. J. Physiol. 265, H226-H231, (1993) abstract

Boulay, et al., Modulation of angiotensin II binding affinity by allosteric interaction of polyvinyl sulfate with an intracellular domain of the DuP-753-sensitive angiotensin II receptor of bovine adrenal glomerulosa. Mol. Pharmacol. 41, 809-815, (1992) abstract

Siemens, et al., Biochemical characterization of two distinct angiotensin AT₂ receptor populations in murine neuroblastoma N1E-115 cells. J. Neurochem. 62, 2106-2115, (1994) abstract

Safety

Hazard Codes

Risk Statements

36/37/38

Safety Statements

WGK Germany

Related Categories

... Neuropeptides > Angiotensins

Angiotensin Receptors (178 kb)

MSDS

Certificate of Analysis

More Information