P4107
Sigma

[Leu³¹, Pro³⁴]-Peptide YY

≥95%

Amino Acid Sequence

Tyr-Pro-Ile-Lys-Pro-Glu-Ala-Pro-Gly-Glu-Asp-Ala-Ser-Pro-Glu-Glu-Leu-Asn-Arg-Tyr-Tyr-Ala-Ser-Leu-Arg-His-Tyr-Leu-Asn-Leu-Leu-Thr-Arg-Pro-Arg-Tyr-NH₂

Molecular Formula

C₁₉₅H₂₉₆N₅₄O₅₆

Molecular Weight

4292.76

MDL number

MFCD00678656

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Descriptions

Biochem/physiol Actions

Agonist at Y₁, Y₄, and Y₅ NPY receptors.

Properties

assay

≥95%

Gene Information

human ... PYY(5697)

storage temp.

−20°C

References

Reference

Gobbi, M., et al., Autoradiographic reevaluation of the binding properties of ¹²⁵I-[Leu³¹,Pro³⁴]peptide YY and ¹²⁵I-peptide YY3-36 to neuropeptide Y receptor subtypes in rat forebrain. J. Neurochem. 72, 1663, (1999) abstract

Ferrier, L., et al., Pathways and receptors involved in peptide YY induced contraction of rat proximal colonic muscle in vitro. Gut 46, 370, (2000) abstract

Dumont, Y., et al., Potent and selective tools to investigate neuropeptide Y receptors in the central and peripheral nervous systems: BIB03304 (Y₁) and CGP71683A (Y₅). Can. J. Physiol. Pharmacol. 78, 116, (2000) abstract

Safety

WGK Germany