Palmitoyl-DL-carnitine chloride 

Long-chain acylcarnitine and well-known intermediate in mitochondrial fatty acid oxidation. Modifies myocardial levels of high-energy phosphates and free fatty acids in the heart. Increases erythroid colony formation in culture. Reduces surface negative charge of erythrocytes and myocytes. Reported to affect currents and inhibit endothelium-dependent relaxation induced by acetylcholine and substance P in a dose dependent manner by suppressing the intracellular calcium signal transduction in endothelial cells.

powder

white

H₂O: 25 mg/mL with heat or sonication

−20°C

Nakadate, T., and Blumberg, P.M., Modulation by palmitoylcarnitine of protein kinase C activation. Cancer Res. 47, 6537-6542, (1987) abstract

Shen, J.B. and Pappano, A.J., Palmitoyl-L-carnitine acts like ouabain on voltagecurrentand contraction in guinea pig ventricular cells. Am. J. Physiol. 268, H1027-H1036, (1995) abstract

Inoue, N., et al., Palmitoyl-L-carnitine modifies the function of vascular endothelium. Cardiovasc. Res. 28, 129-134, (1994) abstract

Stapleton, S.R., et al., Palmitoyl-DL-carnitine has calcium-dependent effects on cultured neurones from rat dorsal root ganglia. Br. J. Pharmacol. 107, 1192-1197, (1992) abstract

Liu, Q.Y., and Rosenberg, R.L., Activation and inhibition of reconstituted cardiac L-type calcium channels by palmitoyl-L-carnitine. Biochem. Biophys. Res. Commun. 228, 252-258, (1996) abstract

Xiao, C.Y., et al., Palmitoyl-L-carnitine modifies the myocardial levels of high-energy phosphates and free fatty acids. Basic Res. Cardiol. 92, 320-330, (1997) abstract

Gruver, C., and Pappano, A.J., Effect of membrane incorporation of 1-palmitoylcarnitine on surface charge of human erythrocytes. J. Mol. Cell. Cardiol. 25, 1275-1284, (1993) abstract

Matsumura, M., et al., Effect of L-carnitine and palmitoyl-L-carnitine on erythroid colony formation in fetal mouse liver cell culture. Am. J. Nephrol. 18, 355-358, (1998) abstract

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