Prostaglandin E₂ 

Most biologically active prostaglandin. PGE₂ induces cervical ripening and parturition; mediates bradykinin-induced vasodilation; regulates adenylyl cyclase. Tumor cells that over-express cyclooxygenase 2 display increased invasiveness, angiogenesis, and resistance to apoptosis that may be due to the PGE₂-induced expression of angiogenic factors and stabilization of the anti-apoptotic protein, survivin.

synthetic

≥99% (TLC)

−20°C

Jackson, G.M., et al., Cervical ripening before induction of labor: a randomized trial of prostaglandin E₂ gel versus low-dose oxytocin. Am. J. Obstet. Gynecol. 171, 1096-1092, (1994)

Fosslein, E., Review: molecular pathology of cyclooxygenase-2 in cancer-induced angiogenesis. Ann. Clin. Lab. Sci. 31, 325-348, (2001)

Krysan, K. et al., COX-2-dependent stabilization of survivin in non-small cell lung cancer. FASEB J. 18, 206-208, (2004)

Coleman, R.A., Classification of prostanoid receptors: properties, distribution, and structure of the receptors and their subtypes. Pharmacol. Rev. 46, 205, (1994) abstract

Merck 13,7969

3

UK8000000