Part I. Signaling Mechanisms Initiated by Cell Surface Receptors. G Protein-Coupled Receptors and G Proteins,
G-Proteins Large and Small Guanine Nucleotide Binding Proteins: Cellular Communication Networks,
The Insulin Receptor Kinase: Regulation and Therapeutic Significance,
Growth Hormone Action: Signaling via a JAK/STAT-Coupled Receptor,
Regulation of Drosophila Visual Transduction Through a Supramolecular Signaling Complex,
Dictyostelium: A Model Experimental System for Elucidating the Pathways and Mechanisms Controlling Chemotaxis,
gp130-Related Cytokines,
Part II. Signaling Mechanisms Mediated by Ion Channels Calcium and Lipids. Ion Channels,
Calcium Ions as Intracellular Messengers: Pathways and Actions,
Calcium and Calmodulin-Mediated Regulatory Mechanisms,
Protein Kinase C, .
Nitric Oxide,
Phospholipids,
Part III. Cyclic AMP, Protein Kinases and Protein Phosphatases. Adenylyl Cyclases,
Cyclic Nucleotide Phosphodiesterases, Marco Conti. Cyclic Nucleotide-Dependent Protein Kinases,.
Protein Serine/Threonine Kinases, .
Protein Serine/Threonine Phosphatases, Shirish Shenolikar. Protein Tyrosine Phosphatases,
Part IV. Signaling Mechanisms Initiated by Nuclear Receptors. The Mechanism of Action of Steroid Hormone Receptors,
Orphan Receptors, Deepak S. Lala and Richard A. Heyman. Coactivators and Corepressors,
CREB Binding Protein-Coactivator Complexes,
Part V. Molecular Regulation of Cell Proliferation and Death. Cell Cycle Checkpoints,
Molecular Regulation of Apotosis, Rosemary B. Evans-Storms and John A. Cidlowski. T-Cells and Immunosuppression,
Part VI. Rational Drug Discovery. Rational Drug Discovery and the Impact of New Advanced Technologies,
Index.
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