P6149
Sigma

Progesterone

Synthetic, from plant source, powder, γ-irradiated, cell culture tested

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Synonym

4-Pregnene-3,20-dione

Molecular Formula

C₂₁H₃₀O₂

Molecular Weight

314.46

CAS Number

57-83-0

Beilstein Registry Number

1915950

MDL number

MFCD00003658

PubChem Substance ID

24898649

EG/EC Number

200-350-6

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Descriptions

Other Notes

Steroid hormone produced by the corpus luteum.

Reconstitution

To prepare 20 μg/ml stock solution, add 1 ml absolute ethanol, gently swirl to dissolve, add 49 ml sterile medium.

Physical form

powder-RT; stock-frozen in working aliquots, avoid repeated freeze/thaw

Biochem/physiol Actions

Induces maturation and secretory activity of the uterine endothelium; suppresses ovulation. Progesterone is implicated in the etiology of breast cancer.

Properties

sterility

γ-irradiated

form

powder

potency

0.1-20 ng/mL

128-132 °C(lit.)

suitability

cell culture tested

Gene Information

human ... ABCB1(5243), AR(367), CYP2C9(1559), EBP(10682), ESR1(2099), ESR2(2100), NR3C1(2908), NR3C2(4306), PGR(5241), SERPINA6(866)

rat ... Ar(24208), Nr3c1(24413), Pgr(25154)

mouse ... Esr1(13982)

References

Reference

Qiu, M., and Lange, C.A., MAP kinases couple multiple functions of human progesterone receptors: degradation, transcriptional synergy, and nuclear association. J. Steroid Biochem. Mol. Biol. 85, 147-157, (2003)

Lanari, C., and Molinolo, A.A., Progesterone receptors--animal models and cell signalling in breast cancer. Diverse activation pathways for the progesterone receptor: possible implications for breast biology and cancer. Breast Cancer Res. 4, 240-243, (2002)

Anderson, E., The role of oestrogen and progesterone receptors in human mammary development and tumorigenesis. Breast Cancer Res. 4, 197-201, (2002)

Rider, V., Progesterone and the control of uterine cell proliferation and differentiation. Front. Biosci. 7, 1545-1555, (2002)

Albrecht, E.D., and Pepe, G.J., Steroid hormone regulation of angiogenesis in the primate endometrium. Front. Biosci. 8, 416-429, (2003)

Merck

Merck 13,7864

Beilstein

Beil. 7,IV,2395

reference

Aldrich MSDS 1, 1539:B / Corp MSDS 1 (2), 2944:C / FT-IR 2 (3), 4228:C / FT-IR 1 (2), 1052:B / FT-NMR 1 (3), 578:A / IR-Spectra (3), 1496:F / RegBook 1 (2), 2859:O / Sax 6, 2290 / Sigma FT-IR 1 (1), 1316:A / Structure Index 1, 458:D:3

Safety

Hazard Codes

Risk Statements

Safety Statements

36/37

WGK Germany

RTECS

TW0175000