P6532
Sigma

Prostaglandin E₂

powder, γ-irradiated, cell culture tested

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Synonym

Dinoprostone

PGE₂

(5Z,11α,13E,15S)-11,15-Dihydroxy-9-oxoprosta-5,13-dienoic acid

Molecular Formula

C₂₀H₃₂O₅

Molecular Weight

352.47

CAS Number

363-24-6

Beilstein Registry Number

4709356

MDL number

MFCD00077861

PubChem Substance ID

24898775

EG/EC Number

206-656-6

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Descriptions

Physical form

powder-0 °C; stock-frozen in working aliquots, avoid repeated freeze/thaw

Biochem/physiol Actions

Most biologically active prostaglandin. PGE₂ induces cervical ripening and parturition; mediates bradykinin-induced vasodilation; regulates adenylyl cyclase. Tumor cells that over-express cyclooxygenase 2 display increased invasiveness, angiogenesis, and resistance to apoptosis that may be due to the PGE₂-induced expression of angiogenic factors and stabilization of the anti-apoptotic protein, survivin.

Properties

sterility

γ-irradiated

form

powder

potency

0.25-100 ng/mL

solubility

ethanol: 1 mg/mL

suitability

cell culture tested

Gene Information

human ... PTGER1(5731), PTGER2(5732), PTGER3(5733), PTGER4(5734), PTGIR(5739)

mouse ... Ptger1(19216), Ptger2(19217), Ptger3(19218), Ptger4(19219)

storage temp.

−20°C

References

Reference

Krysan, K. et al., COX-2-dependent stabilization of survivin in non-small cell lung cancer. FASEB J. 18, 206-208, (2004)

Fosslein, E., Review: molecular pathology of cyclooxygenase-2 in cancer-induced angiogenesis. Ann. Clin. Lab. Sci. 31, 325-348, (2001)

Merck

Merck 13,7969

Safety

Hazard Codes

Risk Statements

60-22

Safety Statements

53-22-26-36/37/39

WGK Germany

RTECS

UK8000000

8-10

Related Categories

... Hematopoietic Stem Cell Expansion/Differentiation > Media Supplements

... Reagents and Supplements > Miscellaneous Reagents and Supplements

... Fatty Acids > Prostaglandins

MSDS

Specification Sheet

Certificate of Analysis

Certificate of Origin

More Information

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powder, γ-irradiated, cell culture tested

Prostaglandin E₂