P8139
Sigma

Phorbol 12-myristate 13-acetate

≥99% (TLC), film or powder

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Synonym

12-O-Tetradecanoylphorbol 13-acetate

4β,9α,12β,13α,20-Pentahydroxytiglia-1,6-dien-3-one 12-tetradecanoate 13-acetate

PMA

TPA

Molecular Formula

C₃₆H₅₆O₈

Molecular Weight

616.83

CAS Number

16561-29-8

Beilstein Registry Number

2407201

MDL number

MFCD00036736

PubChem Substance ID

24278653

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Descriptions

Biochem/physiol Actions

Potent tumor promoter; activates protein kinase C in vivo and in vitro.

Caution

Photosensitive

Properties

assay

≥99% (TLC)

form

film or powder

solubility

DMSO: Dissolve in water-miscible organic solvent prior to preparing aqueous solutions. DMSO solutions can be stored dark at -20 °C for at least six months.soluble

ethanol: Dissolve in water-miscible organic solvent prior to preparing aqueous solutions.soluble

storage temp.

−20°C

References

Reference

Schmidt, R., and Hecker, E., Autoxidation of phorbol esters under normal storage conditions. Cancer Res. 35, 1375-1377, (1975)

Hsu, T.C., et al., Activator protein 1 (AP-1)- and nuclear factor κB (NF-κB)-dependent transcriptional events in carcinogenesis. Free Radic. Biol. Med. 28, 1338-1348, (2000)

Daniel, L.W., et al., Phospholipase D, tumor promoters, proliferation and prostaglandins. Biochim. Biophys. Acta 1439, 265-276, (1999)

Liu, W.S., and Heckman, C.A., The sevenfold way of PKC regulation. Cell. Signal. 10, 529-542, (1998)

Safety

Hazard Codes

Risk Statements

Safety Statements

36/37

WGK Germany

RTECS

QH4377000