P8399
Sigma

Psoralen

≥99%

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Synonym

7H-Furo[3,2-g]benzopyran-7-one

Furo[3,2-g]coumarin

Molecular Formula

C₁₁H₆O₃

Molecular Weight

186.16

CAS Number

66-97-7

Beilstein Registry Number

152784

MDL number

MFCD00010520

PubChem Substance ID

24898918

EG/EC Number

200-639-7

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Descriptions

Application

Photochemical reagent for the investigation of nucleic acid structure and function.^1,^2,^3,⁴

Biochem/physiol Actions

Phototoxic phytoalexin; when activated by UV light, psoralen induces interstrand cross-links in DNA.

Properties

assay

≥99%

storage temp.

2-8°C

References

Cited Reference

1. Cimino, G.D. et al. Annu. Rev. Biochem. 54, 1151, (1985)

2. Kanne, D. et al. J. Am. Chem. Soc. 104, 6754, (1982)

3. Inman, R.B. and Schnös, M., Electron microscopic identification of supercoiled regions in complex DNA structures J. Mol. Biol. 193, 377-384, (1987)

4. Ussery, D.W., et al. Meth. Enzymol., (1992) 212, 242

Reference

Kornhauser, A., et al., Psoralen phototoxicity: correlation with serum and epidermal 8-methoxypsoralen and 5-methoxypsoralen in the guinea pig. Science 217, 733-735, (1982) abstract

Cullinane, C., and Bohr, V.A., DNA interstrand cross-links induced by psoralen are not repaired in mammalian mitochondria. Cancer Res. 58, 1400-1404, (1998) abstract

Merck

Merck 13,8019

Beilstein

Beil. 19,V,4,445

Safety

Hazard Codes

Risk Statements

22-36/37/38

Safety Statements

WGK Germany

RTECS

LV0944000