P8828
Sigma

Pergolide mesylate salt

≥98%, solid

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Synonym

Pergolide methanesulfonate salt

8β-[(Methylthio)methyl]-6-propylergoline methanesulfonate salt

Molecular Formula

C₁₉H₂₆N₂S · CH₄O₃S

Molecular Weight

410.59

CAS Number

66104-23-2

MDL number

MFCD00153859

PubChem Substance ID

24277927

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Descriptions

Biochem/physiol Actions

Dopaminergic agonist; suppresses pituitary secretion of prolactin; anti-Parkinsonian agent.

Properties

assay

≥98%

form

solid

optical activity

[α]20/D −35°, c = 0.2 in pyridine(lit.)

color

white

solubility

ethanol: 2 mg/mL

DMSO: 5.2 mg/mL

H₂O: insoluble

Gene Information

human ... DRD1(1812), DRD2(1813), DRD3(1814), DRD4(1815), DRD5(1816)

storage temp.

−20°C

References

Reference

Barone, et al., Pergolide monotherapy in the treatment of early PD: a randomized, controlled study. Pergolide Monotherapy Study Group. Neurology 53, 573-579, (1999) abstract

Coldwell, et al., Comparison of the functional potencies of ropinirole and other dopamine receptor agonists at human D2(long) D3 and D4.4 receptors expressed in Chinese hamster ovary cells. Br. J. Pharmacol. 127, 1696-1702, (1999) abstract

Linazasoro, et al., Modification of dopamine D2 receptor activity by pergolide in Parkinson's disease: an in vivo study by PET. Clin. Neuropharmacology 22, 277-280, (1999)

Safety

Hazard Codes

T+

Risk Statements

Safety Statements

28-36/37-45

RIDADR

UN 1544 6.1/PG 2

WGK Germany

RTECS

KE6345000