P8887
Sigma

5α-Pregnan-3α-ol-20-one

solid

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Synonym

3α-Hydroxy-5α-pregnan-20-one

3α-OH-DHP

Allopregnan-3α-ol-20-one

Molecular Formula

C₂₁H₃₄O₂

Molecular Weight

318.49

CAS Number

516-54-1

Beilstein Registry Number

3211363

MDL number

MFCD00003677

PubChem Substance ID

24278659

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Descriptions

Biochem/physiol Actions

Positive allosteric modulator of GABA_A chloride channel.

Properties

form

solid

color

white

solubility

DMSO: 5 mg/mL

methanol: soluble

Gene Information

human ... GABRA1(2554), GABRA2(2555), GABRA3(2556), GABRA4(2557), GABRA5(2558), GABRA6(2559), GABRB1(2560), GABRB2(2561), GABRB3(2562)

References

Reference

Bitran, et al., Anxiolytic effects of 3α-hydroxy-5α(β)-pregnan-20-one: endogenous metabolites of progesterone that are active at the GABA_A receptor. Brain Res. 561, 157, (1991) abstract

Mok, et al., In vivo studies identify 5-α-pregnan-3α-ol-20-one as an active anesthetic agent. J. Neurochem. 57, 1296-1296, (1991)

Merck

Merck 13,272

Beilstein

Beil. 8,IV,664

Safety

Safety Statements

22-24/25

WGK Germany

RTECS

TU4383000

Related Categories

... Ligand-Gated Ion Channels > GABA and Glycine Receptor Modulators

... GABAergics > Others

FT-NMR

MSDS

Specification Sheet

Certificate of Analysis

Certificate of Origin

More Information