Peroxiredoxin 1 human 

Peroxiredoxins are a novel defined family of peroxidases of approximately 25 kDa that reduce H₂O₂ and alkyl hydroperoxides and use mainly the thioredoxin (Trx) system (Trx, thioredoxin reductase and NADPH) as electron donor. The peroxiredoxin family includes more than 30 proteins from organisms of all kingdoms. Peroxiredoxin I belongs to the Type I Peroxiredoxin family. This family consists of human natural killer cell enhancing factor (NKEFA), human proliferation associated gene (PAG), mouse macrophage stress induced protein (MSP23), mouse osteoblast specific factor (OSF-3), and rat heme-binding protein (HBP23). These proteins share about 95% homology.

This product has been shown to catalyze NADPH oxidation in the thioredoxin-thioredoxin reductase system.

Lyophilized powder containing HEPES buffer salts and trehalose as stabilizer.

Peroxiredoxin 1, an active enzyme, has two cysteine residues which correspond to Cys 47 and Cys 170 of yeast TPx (thioredoxin peroxidase).

expressed in Escherichia coli

≥85% (SDS-PAGE)

lyophilized powder

human ... PRDX1(5052)

wet ice

−20°C

Chae, H.Z., et al. Proc. Natl. Acad. Sci. USA 91, 7017-7021, (1994) abstract

Chae, H.Z., et al. J. Biol. Chem. 269, 27670, (1994) abstract

Rhee, S.G., et al. Biofactors 10, 207-209, (1999) abstract

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