Phytic acid calcium salt 

Phytic acid is present in all eukaryotic cells. In plants, it is known to function as a [PO₄]³⁻ storage depot and precursor for other inositol phosphates and pyrophosphates. Its high surface negative charge makes it a potent chelator of divalent and trivalent cations in vitro, and it is most likely associated with Ca²⁺ or Mg²⁺ ions in vivo. In yeast, phytic acid acts with the nuclear pore protein Gle1 to regulate the nuclear export of mRNA by coactivating the RNA-dependent ATPase activity of DExD-box protein 5 (Dbp5).

Derived from P 3168

~90%

Shears, S.B., Assessing the omnipotence of inositol hexakisphosphate. Cell. Signal. 13, 151-158, (2001)

Alcazar-Roman, A.R., et al., Inositol hexakisphosphate and Gle1 activate the DEAD-box protein Dbp5 for nuclear mRNA export. Nat. Cell Biol. 8, 711-716, (2006)

Raboy, V., myo-Inositol-1,2,3,4,5,6-hexakisphosphate. Phytochemistry 64, 1033-1043, (2003)

Weirich, C.S., et al., Activation of the DExD/H-box protein Dbp5 by the nuclear-pore protein Gle1 and its coactivator InsP₆ is required for mRNA export. Nat. Cell Biol. 8, 668-676, (2006)

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