R118
Sigma

Risperidone

solid

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Synonym

R 64,766

Molecular Formula

C₂₃H₂₇FN₄O₂

Molecular Weight

410.48

CAS Number

106266-06-2

MDL number

MFCD00274576

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Descriptions

Biochem/physiol Actions

D₂ dopamine receptor antagonist; 5-HT₂ serotonin receptor antagonist; antipsychotic.

Properties

form

solid

color

white

solubility

45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 1.7 mg/mL

ethanol: 17 mg/mL

H₂O: insoluble

Gene Information

human ... DRD2(1813), HRH1(3269), HTR2A(3356), HTR2B(3357), HTR2C(3358)

References

Reference

Leysen, et al., Risperidone: A novel antipsychotic with balanced serotonin-dopamine antagonism, receptor occupancy profile, and pharmacologic activity. J. Clin. Psychiatry 55, 5-12, (1994)

Bergqvist, P.B., Effect of atypical antipsychotic drugs on 5-HT₂ receptors in the rat orbito-frontal cortex: an in vivo electrophysiological study. Psychopharmacology 143, 89, (1999) abstract

Assie, et al., Biphasic displacement of [³H]YM-09151-2 binding in the rat brain by thioridzinerisperidone and clozapine but not by other antipsychotics. Eur. J. Pharmacol. 237, 183, (1993) abstract

Sumiyoshi, et al., In vivo dopamine D₂ and serotonin 5-HT₂ receptor binding study of risperidone and haloperidol. Pharmacol. Biochem. Behav. 47, 553-557, (1994) abstract

Safety

Hazard Codes

Risk Statements

Safety Statements

28-36-45

RIDADR

UN 2811 6.1/PG 3

WGK Germany

RTECS

UV1164800

Celltransmissions 20(1) (74kb)

MSDS

Certificate of Analysis

More Information