all trans-Retinal 

All-trans retinal is converted to retinoic acid in vivo by the action of retinal dehydrogenase. Retinoic acid is a ligand for both the retinoic acid receptor (RAR) and the retinoid X receptor (RXR) that act as transcription factors to regulate the growth and differentiation of normal and malignant cells. Retinal isomers are also chromophores that binds to opsins, a family of G-protein-linked transmembrane proteins, to form photosensitive receptors in visual and nonvisual systems. All-trans retinal is a potent photosensitizer.

Sealed ampule.

≥98%

powder

yellow

dry ice

−20°C

Blomhoff, R., and Blomhoff, H.K., Overview of retinoid metabolism and function. J. Neurobiol. 66, 606-630, (2006)

Terakita, A., The opsins. Genome Biol. 6, 213, (2005)

Wolf, G., A newly discovered visual cycle necessary for vision during continuous illumination. Nutr. Rev. 60, 62-65, (2002)

Merck 13,8249

3

VH6407000