Rutin hydrate 

A polyphenolic flavonoid that acts as an antioxidant and NO scavenger. It can attenuate peroxide production in glial cells by acting as a free radical scavenger and protect renal cells from oxidative injury. Inclusion of rutin in the diet of rats significantly reduced the appearance of single-strand breaks in nuclear DNA caused by hepatocarcinogens aflatoxin B₁ and N-nitrosodimethylamine. This protection from DNA damage was found to be due to a reduction in the induction of repair enzymes polymerase, DNA polymerase β and DNA ligase. Since DNA damage and inefficient repair are thought to initiate the process of carcinogenesis, effects of rutin on these functions suggests a protective role of this flavonoid against carcinogenesis induced by chemical carcinogens.

≥95% (HPLC)

powder

yellow to green

195 °C (dec.)(lit.)

pyridine: 50 mg/mL

DMSO: soluble

aqueous base: soluble

van Acker, S.A., et al., Flavonoids as scavengers of nitric oxide radical. Biochem. Biophys. Res. Commun. 214, 755-759, (1995) abstract

Webster, R.P., et al., Protective effect of rutin, a flavonol glycoside, on the carcinogen-induced DNA damage and repair enzymes in rats. Cancer Lett. 109, 185-191, (1996) abstract

Yokozawa, T., et al., Protective effects of some flavonoids on the renal cellular membrane. Exp. Toxicol. Pathol. 51, 9-14, (1999)

Mazzio, E.A., et al., Food constituents attenuate monoamine oxidase activity and peroxide levels in C6 astrocyte cells. Planta Med. 64, 603-606, (1998) abstract

Beil. 18,V,5,519

Corp MSDS 1 (2), 3061:D / FT-IR 2 (2), 2510:D / FT-IR 1 (2), 96:D / IR-Spectra (3), 906:H / IR-Spectra (2), 793:F / RegBook 1 (2), 1699:C / Sax 6, 2377 / Sigma FT-IR 1 (1), 710:B

Xn

22

3