S101
Sigma

(R)-(+)-SKF-38393 hydrochloride

≥98% (HPLC), solid

zoom

1 of 1

Molecular Formula

C₁₆H₁₇NO₂ · HCl

Molecular Weight

291.77

CAS Number

81702-42-3

MDL number

MFCD00055189

Expand/Collapse All

Descriptions

Biochem/physiol Actions

D₁ dopamine receptor agonist; active enantiomer of (±)-SKF-38393.

Caution

Light sensitive

Reconstitution

Solutions may be stored for several days at 4 °C.

Properties

assay

≥98% (HPLC)

form

solid

optical activity

[α]22/D +16.1°, c = 1.2 in methanol(lit.)

color

off-white to light tan

solubility

0.1 M HCl: 1.2 mg/mL

ethanol: 3.4 mg/mL

H₂O: 5 mg/mL

aqueous base: unstable

References

Reference

Kaiser, et al., Absolute stereochemistry and dopaminergic activity of enantiomers of 2,3,4,5-tetrahydro-7,8-dihydroxy-1-phenyl-1H-benzazepine. J. Med. Chem. 25, 697, (1982) abstract

Ongini, E., et al., Stimulation of dopamine D₁ receptors by SKF-38393 induces EEG desynchronization and behavioral arousal. Life Sci. 37, 2327, (1985) abstract

Katz and Witkin., Effects of quinpirole and SKF-38393 alone and in combination in squirrel monkeys trained to discriminate cocaine. Psychopharmacology 107, 217-220, (1992) abstract

Safety

Hazard Codes

Risk Statements

36/37/38

Safety Statements

WGK Germany

Related Categories

... Dopaminergics > Agonists

Dopamine Receptors (166 kb)

MSDS

Certificate of Analysis

More Information