S1300
Sigma

Monoclonal Anti-L-Selectin (CD62L) antibody produced in mouse

2 mg/mL, clone FMC46, purified immunoglobulin, buffered aqueous solution

Synonym

Anti-L-Selectin

Monoclonal Anti-CD62L

Descriptions

Antigen Background

CD62L, a glycoprotein and member of the selectin family of adhesion receptors, is constitutively expressed on all classes of leukocytes including lymphocytes, monocytes, and polymorphonuclear cells. It is expressed on myeloid progenitor cells, erythroid precursor cells, and some thymocytes.

Immunogen

human PHA-activated peripheral blood mononuclear cells.

Specificity

Recognizes the CD62L (L-Selectin, LAM-1, Leu8, TQ1, LECAM-1, LECCAM-1, DREG) surface antigen. The antibody recognizes an epitope localized to the lectin domain. It inhibits “rolling” interactions and significantly reduces the binding of FITC-yeast phosphomannan monoester core polysaccharide to lymphocytes, monocytes and neutrophils.
5^th Workshop: Code No. S061

Physical form

Solution, 0.2 μm filtered, in 0.01 M phosphate buffered saline, pH 7.4.

Properties

antibody form

purified immunoglobulin

clone

FMC46

form

buffered aqueous solution

mol wt

antigen mol wt 74-95 kDa

species reactivity