S2275
Sigma

Acetyl-[Arg⁶, Sar⁹, Met(O₂)¹¹]-Substance P Fragment 6-11

≥95%

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Amino Acid Sequence

Acetyl-Arg-Phe-Phe-Sar-Leu-Met[O₂]-NH₂

Molecular Formula

C₄₀H₆₀N₁₀O₉S

Molecular Weight

857.03

CAS Number

121951-71-1

MDL number

MFCD00076798

PubChem Substance ID

24899517

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Descriptions

Biochem/physiol Actions

Selective NK-1 receptor agonist.

Properties

assay

≥95%

Gene Information

human ... TAC1(6863)

storage temp.

−20°C

References

Reference

Regoli, D., et al., New selective agonists for neurokinin receptors: pharmacological tools for receptor characterization. Trends Pharmacol. Sci. 9, 290-295, (1988) abstract

Heath, M.J., et al., Functional expression of the tachykinin NK1 receptor by floor plate cells in the embryonic rat spinal cord and brainstem. J. Physiol. 486, 139-148, (1995) abstract

Canning, B.J., and Undem, B.J., Evidence that antidromically stimulated vagal afferents activate inhibitory neurones innervating guinea-pig trachealis. J. Physiol. 480, 613-625, (1994) abstract

Safety

WGK Germany