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S4447 
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α-Synuclein E46K human 

recombinant, expressed in Escherichia coli, N-terminal histidine tagged, ≥90% (SDS-PAGE), lyophilized powder  
Synonym 
non A4 component of amyloid precursor
 
 
PARK1
 
 
PARK4
 
 
PD1
 
 
NACP (Non-a-beta component of Alzheimer disease amyloid, precursor)

 
 
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Descriptions
Biochem/physiol Actions  
Among the familial mutations of α-synuclein in Parkinson's disease, E46K has the greatest potential to aggregate.1,2 This mutation is a 188G-A tran­sition resulting in a Glu46-to-Lys (E46K) substitution in the amino-terminal region of the protein.
 
Properties
recombinant 
expressed in Escherichia coli
 
assay 
≥90% (SDS-PAGE)
 
form 
lyophilized powder
 
mol wt 
apparent mol wt 19-20 kDa
 
Gene Information 
human ... SNCA(6622)
 
shipped in 
dry ice
 
storage temp. 
−20°C
References
Cited Reference 
1. Pandey, N., et al., The α-synuclein mutation E46K promotes aggregation in cultured cells. Exp. Neurol. 197, 515-520, (2006)
 
 
2. Zarranz, J.J., et al., The new mutation, E46K, of α-synuclein causes Parkinson and Lewy body dementia. Ann. Neurol. 55, 164-173, (2004)
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S4447 - Datasheet (76kb)
 
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