S5321
Sigma

S15535

≥98% (HPLC), solid

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Synonym

1-(2,3-Dihydro-1,4-benzodioxin-5-yl)-4-(2,3-dihydro-1h-inden-2-yl)-piperazine

Molecular Formula

C₂₁H₂₄N₂O₂

Molecular Weight

336.43

CAS Number

146998-34-7

MDL number

MFCD00911672

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Descriptions

Biochem/physiol Actions

Potent, orally active, partial 5-HT_1A receptor agonist

Properties

assay

≥98% (HPLC)

form

solid

color

white

solubility

DMSO: ~6 mg/mL

H₂O: insoluble

storage temp.

2-8°C

References

Reference

Millan, M.J., et al., The Serotonin1A Receptor Partial Agonist S15535 [4-(Benzodioxan-5-yl)1-(indan-2-yl)piperazine] Enhances Cholinergic Transmission and Cognitive Function in Rodents: A Combined Neurochemical and Behavioral Analysis J. Pharmacol. Exp. Ther. 311, 190-203, (2004) abstract

Dekeyne, A., et al., The selective serotonin (5-HT)1A receptor ligand, S15535, displays anxiolytic-like effects in the social interaction and Vogel models and suppresses dialysate levels of 5-HT in the dorsal hippocampus of freely-moving rats. A comparison with other anxiolytic agents Psychopharmacology 152, 55-66, (2000) abstract

Safety

Hazard Codes

Risk Statements

Safety Statements

RIDADR

UN 3077 9/PG 3