Streptokinase from β-hemolytic Streptococcus (Lancefield Group C) 

Streptokinase is commonly used as a thrombolytic agent in the therapy of ischemic stroke. This therapy carries the important risk of intracerebral hemorrhage. Streptokinase is also used in the treatment of complicated parapneumonic effusions and empyema where adverse reactions, allergic type, are rare.

One unit will liquify a standard clot of fibrinogen, plasminogen, and thrombin at pH 7.5 at 37 °C in 10 min.

Solution containing 60 mM phosphate buffer and 0.6 M glutamate

buffered aqueous solution

dry ice

−20°C

Bull. Wld. Hlth. Org. 33, 235, (1965)

Bouros D, Schiza S, Siafakas N, Fibrinolytics in the treatment of parapneumonic effusions. Monaldi Arch. Chest Dis. 54, 258-263, (1999)

Barletta JF., Streptokinase and urokinase for the treatment of pleural effusions and empyemas. Pharmacotherapy 33, 495-498, (1999)

Hacke W, Ringleb P, Stingele R., Update in thrombolytic therapy. Rev. Neurol. (Paris) 155, 662-665, (1999)

Merck 13,8903

22-24/25

2

OB8880000

10-21