T1443
Sigma

TCPOBOP

≥98% (HPLC), solid

zoom

1 of 1

Synonym

1,4-Bis-[2-(3,5-dichloropyridyloxy)]benzene

3,3′,5,5′-Tetrachloro-1,4-bis(pyridyloxy)benzene

Molecular Formula

C₁₆H₈N₂O₂Cl₄

Molecular Weight

402.06

CAS Number

76150-91-9

MDL number

MFCD00057368

PubChem Substance ID

24278723

Expand/Collapse All

Descriptions

Biochem/physiol Actions

TCPOBOP enhances the nuclear receptor CAR transactivation of cytochrome P450 (CYP), as dose-dependent direct agonist of CAR. The most potent known member of the phenobarbital-like class of CYP-inducing agents.

Properties

assay

≥98% (HPLC)

form

solid

color

white

solubility

DMSO: >10 mg/mL

H₂O: insoluble

Gene Information

human ... NR1I3(9970)

storage temp.

2-8°C

References

Reference

Tzameli, I. et al., The xenobiotic compound 1,4-bis[2-(3,5-dichloropyridyloxy)] benzene is an agonist ligand for the nuclear receptor CAR. Mol. Cell. Biol. 20, 2951, (2000)

Ledda-Columbano, G., Early increase in cyclin-D1 expression and accelerated entry of mouse hepatocytes into S phase after administration of the mitogen 1, 4-Bis[2-(3,5-Dichloropyridyloxy)] benzene. Am. J. Pathol. 156, 91, (2000)

Kende, A.S., et al. , Structure-activity relationship of bispyridyloxybenzene for induction of mouse hepatic aminopyrine N-demethylase activity. Chemical, biological, and X-ray crystallographic studies. Mol. Pharmacol. 28, 445, (1985)

Safety

Safety Statements

22-24/25

WGK Germany

RTECS

UT7145000