T1566
Sigma

Tie-1/Fc Chimera human

≥90% (SDS-PAGE), recombinant, expressed in mouse NSO cells, lyophilized powder, cell culture tested

Synonym

Tyrosine kinase with Ig and EGF homology domains 1

MDL number

MFCD02100724

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Descriptions

Biochem/physiol Actions

Tie (tyrosine kinase with Ig and EGF homology domains) receptors Tie-1 and Tie-2 are receptor tyrosine kinase (RTK) family members with unique structural characteristics that involve their two Ig-like, three EGF-like and three fibronectin III-like motifs in the extracellular domain. They also have a split tyrosine kinase domain in the cytoplasmic region. They are expressed primarily on endothelial cells and hematopoietic progenitors. Tie-1 and Tie-2 are thought to play critical roles in angiogenesis and hematopoiesis. Tie-1 is related to endothelial cell differentiation and maintenance of endothelium integrity.

Physical form

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline.

Properties

recombinant

expressed in mouse NSO cells

assay

≥90% (SDS-PAGE)

form

lyophilized powder

total impurities

Endotoxin, tested

suitability

cell culture tested

Gene Information

human ... TIE1(7075)

storage temp.

−20°C

References

Reference

Puri, M.C., et al., The receptor tyrosine kinase Tie is required for integrity and survival of vascular endothelial cells. EMBO J. 14, 5884-5891, (1995) abstract

Partanen, J. and Dumont, D.J., Functions of Tie1 and Tie2 receptor tyrosine kinases in vascular development. Curr. Top. Microbiol. Immunol. 237, 159-172, (1999)

Sato, T.N., et al., Distinct roles of the receptor tyrosine kinases Tie-1 and Tie-2 in blood vessel formation. Nature 376, 70-74, (1995) abstract