T1633
Sigma

Theophylline

anhydrous, ≥99%, powder

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Synonym

1,3-Dimethylxanthine

2,6-Dihydroxy-1,3-dimethylpurine

3,7-Dihydro-1,3-dimethyl-1H-purine-2,6-dione

Molecular Formula

C₇H₈N₄O₂

Molecular Weight

180.16

CAS Number

58-55-9

Beilstein Registry Number

13463

MDL number

MFCD00079619

PubChem Substance ID

24277677

EG/EC Number

200-385-7

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Descriptions

Biochem/physiol Actions

Phosphodiesterase inhibitor; diuretic; cardiac stimulant; muscle relaxant; asthma medication.

Properties

grade

anhydrous

assay

≥99%

form

powder

color

white

solubility

0.1 M HCl: soluble

0.1 M NaOH: soluble

H₂O: slightly soluble

ethanol: moderately soluble

Gene Information

mouse ... Adora2b(11541)

rat ... Adora1(29290), Adora2a(25369), Adora2b(29316), Pde1b(29691), Pde3a(50678)

human ... ADORA1(134), ADORA2A(135), ADORA2B(136), ADORA3(140), PDE3A(5139), PDE4B(5142)

References

Reference

Reuter, et al., Phosphodiesterase inhibitors prevent NSAID enteropathy independently of effects on TNF-alpha release. Am. J. Physiol. 277, G8478-G8454, (1999)

Linden, et al., Characterization of human A(2B) adenosine receptors: radioligand binding, western blotting, and coupling to G(q) in human embryonic kidney 293 cells and HMC-1 mast cells. Mol. Pharmacol. 56, 705-713, (1999)

Giri, et al., Mutagenic and genotoxic effects of theophylline and theobromine in Salmonella assay and in vivo sister chromatid exchanges in bone marrow cells of mice. Mutat. Res. 444, 17-23, (1999)

Merck

Merck 13,9356

Beilstein

Beil. 26,IV,2331

Safety

Hazard Codes

Risk Statements

RIDADR

UN 2811 6.1/PG 3

WGK Germany

RTECS

XH3850000