T182
Sigma

Tyrphostin A9

solid

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1 of 1

Synonym

[[3,5-bis(1,1-Dimethylethyl)-4-hydroxyphenyl]methylene]propanedinitrile

Molecular Formula

C₁₈H₂₂N₂O

Molecular Weight

282.38

CAS Number

10537-47-0

MDL number

MFCD00209853

PubChem Substance ID

24278069

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Descriptions

Biochem/physiol Actions

Selective inhibitor of PDGF receptor tyrosine kinase.

Inhibitor of calcium release-activated calcium (CRAC) channels (see Dennis et al)

Properties

form

solid

color

yellow

solubility

ethanol: 20 mg/mL

DMSO: <25 mg/mL

H₂O: insoluble

Gene Information

human ... EGFR(1956), ORAI1(84876), PDGFRA(5156), PDGFRB(5159)

mouse ... Eef2k(13631), Prkaca(18747), Prkca(18750), Src(20779)

References

Reference

Levitzki, A., Gilon, C, Tyrphostins as molecular tools and potential antiproliferative drugs. Trends Pharmacol. Sci. 12, 171-174, (1991) abstract

Bilder, et al., Tyrphostins inhibit PDGF-induced DNA synthesis and associated early events in smooth muscle cells. Am. J. Physiol. 260, C721-C730, (1991) abstract

Denys, A., et al., Thapsigargin-stimulated MAP kinase phosphorylation via CRAC channels and PLD activatory-inhibitory action of docosahexaenoic acid. FEBS Lett. 564, 177-182, (2004) abstract

Safety

Hazard Codes

Risk Statements

23/24/25

Safety Statements

36/37/39-45

RIDADR

UN 2811 6.1/PG 3

WGK Germany

RTECS

OO3737000