T2376
Sigma

L-Thyroxine

≥98% (HPLC)

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Synonym

3,3′,5,5″-Tetraiodo-L-thyronine

T₄

3-[4-(4-Hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl]-L-alanine

Molecular Formula

HOC₆H₂(I)₂OC₆H₂(I)₂CH₂CH(NH₂)CO₂H

Molecular Weight

776.87

CAS Number

51-48-9

Beilstein Registry Number

2228515

MDL number

MFCD00002595

PubChem Substance ID

24900033

EG/EC Number

200-101-1

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Descriptions

Biochem/physiol Actions

L-Thyroxine (T₄) and triiodo-L-thyronine (T₃) are iodine-containing hormones produced from thyroglobulin in the thyroid follicular cells. The stimulation of metabolic rate and regulation of growth and development by these hormones appear to be due to their effects on DNA transcription and, thus, protein synthesis.

Properties

assay

≥98% (HPLC)

223 °C (dec.)(lit.)

Gene Information

mouse ... Cnr2(12802)

human ... TTR(7276)

rat ... Cnr1(25248)

References

Reference

Oppenheimer, J.H., et al., Advances in our understanding of thyroid hormone action at the cellular level. Endocr. Rev. 8, 288-308, (1987)

DeGroot, L.J., and Niepomniszcze, H., Biosynthesis of thyroid hormone: basic and clinical aspects. Metabolism 26, 665-718, (1977)

Dussault, J.H., and Ruel, J., Thyroid hormones and brain development. Annu. Rev. Pharmacol. Toxicol. 49, 321-334, (1987)

Evans, R.M., The steroid and thyroid hormone receptor superfamily. Science 240, 889-895, (1988)

Merck

Merck 13,9491

Beilstein

Beil. 14,IV,2373

reference

Aldrich MSDS 1, 1709:B / Corp MSDS 1 (2), 3349:B / FT-IR 2 (2), 2749:A / FT-IR 1 (2), 254:B / RegBook 1 (2), 1845:F / Sigma FT-IR 1 (1), 724:B / Structure Index 1, 296:B:1

Safety

Safety Statements

22-24/25

WGK Germany

RTECS

YP2833500

8-10