T2501
Sigma

L-Thyroxine sodium salt pentahydrate

≥98% (HPLC), powder

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Synonym

Sodium levothyroxine

T₄

3-[4-(4-Hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl]-L-alanine sodium salt

Molecular Formula

HOC₆H₂I₂OC₆H₂I₂CH₂CH(NH₂)COONa � 5H₂O

Molecular Weight

888.93

CAS Number

6106-07-6

Beilstein Registry Number

5721845

MDL number

MFCD00149110

PubChem Substance ID

24900041

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Descriptions

Biochem/physiol Actions

L-Thyroxine (T₄) and triiodo-L-thyronine (T₃) are iodine-containing hormones produced from thyroglobulin in the thyroid follicular cells. The stimulation of metabolic rate and regulation of growth and development by these hormones appear to be due to their effects on DNA transcription and thus, protein synthesis.

Properties

assay

≥98% (HPLC)

form

powder

207-210 (dec.)(lit.)

Gene Information

rat ... Cnr1(25248)

mouse ... Cnr2(12802)

storage temp.

−20°C

References

Reference

Oppenheimer, J.H., et al., Advances in our understanding of thyroid hormone action at the cellular level. Endocr. Rev. 8, 288-308, (1987)

Evans, R.M., The steroid and thyroid hormone receptor superfamily. Science 240, 889-895, (1988)

Dussault, J.H., and Ruel, J., Thyroid hormones and brain development. Annu. Rev. Pharmacol. Toxicol. 49, 321-334, (1987)

DeGroot, L.J., and Niepomniszcze, H., Biosynthesis of thyroid hormone: basic and clinical aspects. Metabolism 26, 665-718, (1977)

Beilstein

Beil. 14,IV,2374

reference

Aldrich MSDS 1, 1709:C / Corp MSDS 1 (2), 3350:B / FT-IR 2 (2), 2749:B / FT-IR 1 (2), 254:C / FT-NMR 1 (2), 1186:C / IR-Spectra (3), 997:C / IR-Spectra (2), 873:A / RegBook 1 (2), 1845:G / Sigma FT-IR 1 (1), 724:C / Structure Index 1, 296:C:1

Safety

Safety Statements

22-24/25

WGK Germany

RTECS

YP2833760

3-8-10