T3019
Sigma

α-Bungarotoxin from Bungarus multicinctus (Formosan Banded Krait)

solid

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Synonym

α-BuTX

MDL number

MFCD01779815

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Descriptions

Biochem/physiol Actions

Neurotoxin which binds irreversibly to motor endplate of acetylcholine receptors; prevents opening of nicotinic receptor-associated ion channels.

Properties

form

solid

mol wt

mol wt ~8 kDa

color

white

storage temp.

−20°C

References

Reference

Tanowitz, M., et al., Regulation of neuregulin-mediated acetylcholine receptor synthesis by protein tyrosine phosphatase SHP2. J. Neurosci. 19, 9426-9435, (1999) abstract

Akaaboune, M., et al., Rapid and reversible effects of activity on acetylcholine receptor density at the neuromuscular junction in vivo. Science 286, 503-507, (1999) abstract

Court, J., et al., Neuronal nicotinic receptors in dementia with Lewy bodies and schizophrenia: α-bungarotoxin and nicotine binding in the thalamus. J. Neurochem. 73, 1590-1597, (1999) abstract

Safety

WGK Germany

RTECS

QQ4495249