Trehalose 6,6′-dimycolate from Mycobacterium tuberculosis 

Cord factor is a glycolipid released from Mycobacterium that becomes toxic and antigenic when it interacts with cell surface lipids. It activates macrophages to release inflammatory cytokines and induces thymic atrophy and granuloma formation in lung and other organs. It is responsible for the necrosis and cavitation observed in secondary tuberculosis.

~98% 6,6′-mycolate esters basis

−20°C

Fujita, Y., et al., Molecular and supra-molecular structure related differences in toxicity and granulomatogenic activity of mycobacterial cord factor in mice. Microb. Pathog. 43, 10-21, (2007)

Hunter, R.L., et al., Multiple roles of cord factor in the pathogenesis of primary, secondary, and cavitary tuberculosis, including a revised description of the pathology of secondary disease. Ann. Clin. Lab. Sci. 36, 371-386, (2006)

Borders, C.W., et al., Requisite role for complement C5 and the C5a receptor in granulomatous response to mycobacterial glycolipid trehalose 6,6'-dimycolate. Scand. J. Immunol. 62, 123-130, (2005)

Lopez-Marin, L.M., et al., 6,6'-Dimycoloyl trehalose from a rapidly growing Mycobacterium: an alternative antigen for tuberculosis serodiagnosis. FEMS Immunol. Med. Microbiol. 36, 47-54, (2003)

Indrigo, J., et al., Cord factor trehalose 6,6'-dimycolate (TDM) mediates trafficking events during mycobacterial infection of murine macrophages. Microbiology 149, 2049-2059, (2003)