Tubulysin A 

Tubulysin A is a novel antibiotic, which is anti-microtubule, anti-mitotic, apoptosis inducer, anticancer, anti-angiogenic, and antiproliferative. Tubulysins are cytotoxic peptides, which include 9 members (A-I). Tubulysin A has potential application as an anticancer agent. It arrests cells in the G2/M phase. Tubulysin A inhibits polymerization more efficiently than vinblastine and induces depolymerization of isolated microtubules. Tubulysin A has potent cytostatic effects on various tumor cell lines with IC₅₀ in the picomolar range.

from Streptomyces sp.

≥98% (HPLC)

solid

organic solvents: soluble

wet ice

2-8°C

Sasse, F., et al., Tubulysins, new cytostatic peptides from myxobacteria acting on microtubuli. Production, isolation, physico-chemical and biological properties. J. Antibiot. 53, 879-885, (2000)

Kaur, G., et al., Biological evaluation of tubulysin A: a potential anticancer and antiangiogenic natural product. Biochem. J. 396, 235-242, (2006)

Khalil, M.W., et al., Mechanism of action of tubulysin, an antimitotic peptide from myxobacteria. ChemBioChem. 7, 678-683, (2006)

Steinmetz, H., et al., Isolation, crystal and solution structure determination, and biosynthesis of tubulysins--powerful inhibitors of tubulin polymerization from myxobacteria. Angew. Chem. Int. Ed. 43, 48884892, (2004)

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