T3434
Sigma

Tyrphostin�AG�490

solid

1 of 1

Synonym

2-Cyano-3-(3,4-dihydroxyphenyl)-N-(benzyl)-2-propenamide; 2-Cyano-3-(3,4-dihydroxyphenyl)-N-(phenylmethyl)-2-propenamide

Molecular Formula

C₁₇H₁₄N₂O₃

Molecular Weight

294.30

CAS Number

133550-30-8

MDL number

MFCD00209833

PubChem Substance ID

24278732

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Descriptions

Biochem/physiol Actions

Jak-2 protein tyrosine kinase (PTK) inhibitor. Inhibits interleukin 2 (IL-2) driven mitogenesis and triggers apoptosis of tumor cells in Sezary syndrome, a leukemic variant of cutaneous T cell lymphoma.

Caution

Photosensitive

Properties

form

solid

color

yellow

solubility

ethanol: 5 mg/mL

H₂O: insoluble

Gene Information

human ... EGFR(1956), ERBB2(2064), IL2(3558), JAK2(3717)

storage temp.

−20°C

References

Reference

Abe, et al., Fyn and JAK2 mediate Ras activation by reactive oxygen species. J. Biol. Chem. 274, 21003-21010, (1999) abstract

Al-Shami, et al., Granulocyte-macrophage colony-stimulating factor-activated signaling pathways in human neutrophils Involvement of Jak2 in the stimulation of phosphatidylinositol 3-kinase. J. Biol. Chem. 274, 5333, (1999) abstract

Eriksen, K.W., et al., Constitutive STAT3-activation in Sezary syndrome: tyrphostin AG490 inhibits STAT3-activation, interleukin-2 receptor expression and growth of leukemic Sezary cells. Leukemia 15, 787-793, (2001) abstract

Potier, et al., Protein tyrosine kinase inhibitors reduce high-voltage activating calcium currents in CA1 pyramidal neurones from rat hippocampal slices. Brain Res. 816, 587-597, (1999) abstract

Safety

Hazard Codes

Risk Statements

36/37/38

Safety Statements

26-36

WGK Germany