RANK Ligand/TRANCE human 

The biological activity is measured by its ability to induce osteoclast differentiation on mouse splenocytes.

Lyophilized from a 0.2 μm filtered in phosphate buffered saline containing 0.5 mg bovine serum albumin.

RANK Ligand/TRANCE, a member of the TNF superfamily, induces activation of the c-jun N-terminal kinase, enhances T-cell growth and dendritic cell function, induces osteoclastogenesis, and lymph node organogenesis. Mouse and human RANK Ligand share 85% amino acid identity. RANK is the cell surface receptor for RANK Ligand.

expressed in mouse NSO cells

>90% (SDS-PAGE)

lyophilized powder

glycolysylated recombinant product mol wt ~35 kDa by SDS-PAGE

calculated mol wt 23 kDa

Endotoxin, tested

human ... TNFSF11(8600)

−20°C

Anderson, D.M. Nature 390, 175, (1997)

Kong, Y-Y., et al. Nature 397, 315, (1999)