T3694
Sigma

Tetanus toxin C fragment from Clostridium tetani

Synonym

TTC

MDL number

Descriptions

Reconstitution

Each vial, when reconstituted with 50 µl of sterile distilled water, contains 10 µg of tetanus toxin C-fragment in 0.01 M sodium phosphate, pH 7.5. To aid recovery, 0.1% albumin may be added.

Application

The C terminal binding portion of tetanus toxin is not toxic but is taken up by pre-synaptic nerve terminals and exhibits trans-synaptic retrograde transport in central neurons similar to that of tetanus toxin. It is used to map neuronal connections and to target proteins to neurons.

Properties

mol wt

apparent mol wt 47 kDa

color

white

References

Reference

Helting, T.B. , Zwisler, O., Structure of tetanus toxin. I. Breakdown of the toxin molecule and discrimination between polypeptide fragments. . J. Biol. Chem. 252, 187, (1977) abstract

Safety

Hazard Codes

T+

Risk Statements

26/27/28

Safety Statements

WGK Germany

RTECS

XW5807000