T-2 Toxin 

Chromatographically purified

The trichothecenes, such as T2 Toxin, are mycotoxins produced by fungi of the genus Fusarium. They are commonly present in foods and feed of cereal origin. T-2 toxin induces DNA damage and cell death on prolonged administration. These effects can be partially blocked by antioxidants, such as glutathione, coenzyme Q10, or α-tocopherol. Increases blood-brain barrier permeability and inhibits monoamine oxidase activity in brain.

from Fusarium sp.

powder

not available in Japan

white

−20°C

Thuvander, A, et al., In vitro exposure of human lymphocytes to trichothecenes: individual variation in sensitivity and effects of combined exposure on lymphocyte function. Food Chem. Toxicol. 37, 639-648, (1999) abstract

Shinozuka, J., et al., T-2 toxin-induced apoptosis in hematopoietic tissues of mice. Toxicol. Pathol. 26, 674-681, (1998) abstract

Atroshi, F., et al., T-2 toxin-induced DNA damage in mouse livers: the effect of pretreatment with coenzyme Q10 and alpha-tocopherol. Mol. Aspects Med. 18, S255-S258, (1997) abstract

Wang, J., et al., Effect of T-2 toxin on blood-brain barrier permeability monoamine oxidase activity and protein synthesis in rats. Food Chem. Toxicol. 36, 955-961, (1998) abstract

Islam, Z., et al., Structure-function relationship of T-2 toxin and its metabolites in inducing thymic apoptosis in vivo in mice. Biosci. Biotechnol. Biochem. 62, 1492-1497, (1998) abstract

Merck 13,9872

UN 3462 6.1/PG 1

3

YD0100000