T5425
Sigma

Transforming Growth Factor-β3 human

recombinant, expressed in Sf21 cells, powder, cell culture tested

Synonym

TGF-β3

MDL number

MFCD00213054

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Descriptions

Analysis Note

The biological activity is measured by its ability to inhibit the IL-4-dependent proliferation of mouse HT-2 cells.

Biochem/physiol Actions

TGF-β3 is less prevalent in natural expression than either TGF-β1 or TGF-β2, but it is the most abundant mRNA expressed in chick embryos. It is also expressed in human umbilical cord, in a variety of mesenchymal cells of human and rodent origin, and in several human carcinoma cells.

Physical form

Lyophilized from a 0.2 μm filtered solution in 40% acetonitrile and 0.1% trifluoroacetic acid containing 0.1 mg bovine serum albumin.

Properties

recombinant

expressed in Sf21 cells

assay

≥97% (SDS-PAGE)

form

powder

potency

0.01-0.09 ng/mL ED₅₀/EC₅₀

mol wt

predicted mol wt ~25 kDa

total impurities

Endotoxin, tested

suitability

cell culture tested

storage temp.

−20°C

References

Reference

Tsang, M., et al. Proc. 7th Intl. Lymphokine Workshop 9, 607, (1990)

Roberts, A., and Sporn, M., Sporn, M., and Roberts, A., ed. Peptide Growth Factors and their Receptors I New York , (1991), 419-472

Related Categories

... Hematopoietic Stem Cell Expansion/Differentiation > Cytokine/Growth Factor

... Cytokines/Growth Factors/Chemokines > Growth Factors

... Cytokines/Growth Factors/Chemokines > Growth Factors

... Transforming Growth Factor-β (TGF-β) and Superfamily > TGF-β

... Cytokines & Growth Factors > Transforming Growth Factor-b Superfamily Proteins and Peptides

... Growth Factors and Cytokines > Transforming Growth Factors

T5425 - Datasheet (26kb)

MSDS

Specification Sheet

Certificate of Analysis

Certificate of Origin

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