T5442
Sigma

Anti-ADAM-17 (TACE), C-Terminal antibody produced in rabbit

~0.5 mg/mL, affinity isolated antibody, buffered aqueous solution

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Synonym

Anti-TACE

Anti-TNF-α Converting Enzyme

MDL number

MFCD03096588

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Descriptions

Immunogen

synthetic peptide corresponding to the C-terminal amino acids 807-823 of human TNF-α converting enzyme (TACE). This peptide differs from mouse and rat by only one amino acid.

Physical form

Solution in 0.01 M phosphate buffered saline containing 0.02% sodium azide.

Properties

antibody form

affinity isolated antibody

form

buffered aqueous solution

mol wt

antigen mol wt 80-130 kDa (wide band representing mature protein, precursor and glycosylated TACE)

species reactivity

human, mouse, rat

concentration

~0.5 mg/mL

application(s)

immunoblotting: 0.25-1 μg/mL using HeLa or Jurkat cell lysates

microarray: suitable

Gene Information

mouse ... Adam17(11491)

rat ... Adam17(57027)

human ... ADAM17(6868)

shipped in

dry ice

storage temp.

−20°C

References

Reference

Black, R.A., et al., A metalloproteinase disintegrin that releases tumour-necrosis factor-α from cells. Nature 385, 729-733, (1997) abstract

Moss, M.L., et al., Cloning of a disintegrin metalloproteinase that processes precursor tumour-necrosis factor-α. Nature 385, 733-736, (1997) abstract

Mizui, Y., et al., CDNA cloning of mouse tumor necrosis factor-α converting enzyme (TACE) and partial analysis of its promoter. Gene. Gene 233, 67-74, (1999) abstract

Safety

WGK Germany

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Array

XP725, Panorama^® Antibody Microarray - XPRESS Profiler725 Kit

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T5442 - Datasheet (54kb)

T5442-blot (11kb)

MSDS

Certificate of Analysis

More Information