T5651
Sigma

Tetrodotoxin

powder

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1 of 1

Synonym

Fugu poison

Maculotoxin

Tarichatoxin

TTX

Molecular Formula

C₁₁H₁₇N₃O₈

Molecular Weight

319.27

CAS Number

4368-28-9

Beilstein Registry Number

49176

MDL number

MFCD00213719

PubChem Substance ID

24900308

EG/EC Number

224-458-8

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Descriptions

Packaging

Vial contains 1 mg of tetrodotoxin and approx. 5 mg citrate buffer, pH 4.8.

Biochem/physiol Actions

Reversible, selective blocker of Na⁺ channels; blocks propagation of impulses in excitable membranes. Used to characterize sodium channels in excitable membranes and to study the role of sodium channels in normal physiology and disease.

Properties

form

powder

solubility

H₂O: stable at pH 4-5 if stored frozensoluble

strong acid or alkaline solutions: destroyed by boiling at pH 2.unstable

Gene Information

rat ... Scnn1g(24768)

storage temp.

2-8°C

References

Reference

Catterall, W.A., Neurotoxins that act on voltage-sensitive sodium channels in excitable membranes. Annu. Rev. Pharmacol. Toxicol. 20, 15-43, (1980)

Narahashi, T., et al., Recent advances in the study of mechanism of action of marine neurotoxins. Neurotoxicology 15, 545-554, (1994)

Yoshida, S., Tetrodotoxin-resistant sodium channels. Cell. Mol. Neurobiol. 14, 227-244, (1994)

Penzotti, J.L., Differences in saxitoxin and tetrodotoxin binding revealed by mutagenesis of the Na⁺ channel outer vestibule. Biophys. J. 75, 2647, (1998)

Taylor, C.P., and Narasimhan, L.S., Sodium channels and therapy of central nervous system diseases. Adv. Pharmacol. 39, 47-98, (1997)

Merck

Merck 13,9318

Beilstein

Beil. 27,IV,8206

Safety

Hazard Codes

T+

Risk Statements

26/27/28

Safety Statements

22-36/37/39-45

RIDADR

UN 3462 6.1/PG 1

WGK Germany

RTECS

IO1450000

10-18

Related Categories

... Toxins and Venoms > Fish

... Sodium Channel Modulators > Other Sodium Channel Modulators

MSDS

Specification Sheet

Certificate of Analysis

Certificate of Origin

More Information