T5694
Sigma

TRAIL human

recombinant, expressed in mouse NSO cells, >97% (SDS-PAGE), lyophilized powder

Synonym

Apo2 Ligand

Apo2L

TL2

TNF-related apoptosis-inducing ligand

MDL number

MFCD01867158

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Descriptions

Analysis Note

Induces cytotoxicity in mouse L-929 cells in the presence of actinomycin D.

Physical form

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline containing 0.5 mg bovine serum albumin.

Biochem/physiol Actions

Type II transmembrane protein of the TNF superfamily. Ligand for apoptosis-inducing death receptors DR4 and DR5, decoy receptors DcR1 and DcR2, and osteoprotegerin. Approximately 28% amino acid sequence identity to FAS ligand. Human and mouse TRAIL share 65% sequence identity.

Properties

recombinant

expressed in mouse NSO cells

description

N-terminal 6X histidine-tagged extracellular domain

assay

>97% (SDS-PAGE)

form

lyophilized powder

mol wt

mol wt 24 kDa by SDS-PAGE

predicted mol wt ~21 kDa

total impurities

Endotoxin, tested

Gene Information

human ... TNFSF10(8743)

storage temp.

−20°C

References

Reference

Wiley, S.R., et al., Identification and characterization of a new member of the TNF family that induces apoptosis. Immunity 3, 673, (1995) abstract

Simonet, W.S., Osteoprotegerin: a novel secreted protein involved in the regulation of bone density. Cell 89, 309, (1997) abstract

Zhang, X.D., et al., Mechanisms of resistance of normal cells to TRAIL induced apoptosis vary between different cell types. FEBS Lett. 482, 193, (2000) abstract

Strater, J., Moller, P., Expression and function of death receptors and their natural ligands in the intestine. Ann. N.Y. Acad. Sci. 915, 162, (2000) abstract

Safety

Safety Statements

22-24/25-36/37/39-45

Related Categories

... Apoptosis and Cell Cycle > Death Receptor Ligands

Cytokine Receptors Tumor Necrosis Receptor Family (203 kb)

T5694 - Datasheet (29kb)

MSDS

Certificate of Analysis

More Information