T6137
Sigma

Trioxsalen

≥98% (HPLC), powder

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Synonym

2,5,9-Trimethylfuro[3,2-g]benzopyran-7-one

4,5′,8-Trimethylpsoralen

TMP

Trisoralen

Molecular Formula

C₁₄H₁₂O₃

Molecular Weight

228.24

CAS Number

3902-71-4

Beilstein Registry Number

221723

MDL number

MFCD00005010

PubChem Substance ID

24900351

EG/EC Number

223-459-0

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Descriptions

Biochem/physiol Actions

Photochemical crosslinker of DNA that has been used as a probe for nucleic acid structure and function. Trioxsalen has also been used to crosslink DNA onto mica surfaces.

Properties

assay

≥98% (HPLC)

form

powder

color

white

229-231 °C(lit.)

storage temp.

−20°C

References

Reference

Shlyakhtenko, L.S., et al., Atomic force microscopy imaging of DNA covalently immobilized on a functionalized mica substrate. Biophys. J. 77, 568-576, (1999)

Mojica, F.J., and Higgins, C.F., Localized domains of DNA supercoiling: topological coupling between promoters. Mol. Microbiol. 22, 919, (1996)

Botta, R., and Gustavino, B., Relationship between chromatin bridges in anaphase and chromosomal aberrations induced by TMP + UVA (365 nm) in CHO cells. Mutat. Res. 374, 253-259, (1997)

G.D. Cimino Annu. Rev. Biochem. 54, 1151, (1985)

Merck

Merck 13,9805

Beilstein

Beil. 19,V,4,472

reference

Aldrich MSDS 1, 1795:D / Corp MSDS 1 (2), 3494:B / FT-IR 2 (3), 3619:D / FT-IR 1 (2), 684:C / RegBook 1 (2), 2433:C / Sigma FT-IR 1 (1), 731:D / Structure Index 1, 385:D:6

Safety

Hazard Codes

Risk Statements

34-40

Safety Statements

26-36/37/39-45

RIDADR

UN 1759 8/PG 1

WGK Germany

RTECS

LV1576000

8-10

Related Categories

... DNA metabolism > DNA Intercalators and Crosslinkers

FT-IR Raman

MSDS

Certificate of Analysis

Certificate of Origin

More Information