Trichostatin A 

Inhibits histone deacetylase at nanomolar concentrations; resultant histone hyperacetylation leads to chromatin relaxation and modulation of gene expression. May be involved in cell cycle progression of several cell types, inducing cell growth arrest at both G and G/M phases; may induce apoptosis. Enhances the efficacy of anticancer agents that target DNA.

from Streptomyces sp.

≥98% (HPLC)

ethanol: 1 mg/mL

human ... HDAC1(3065), HDAC4(9759), HDAC6(10013), HDAC8(55869)

rat ... Hdac7a(84582)

mouse ... Hdac1-ps(15181)

−20°C

Yoshida, M., et al., Trichostatin A and trapoxin: novel chemical probes for the role of histone acetylation in chromatin structure and function. Bioessays 17, 423-430, (1995) abstract

Brehm, A., et al., Retinoblastoma protein recruits histone deacetylase to repress transcription. Nature 391, 597-601, (1998) abstract

Medina, V., et al., Induction of caspase-3 protease activity and apoptosis by butyrate and trichostatin A (inhibitors of histone deacetylase): dependence on protein synthesis and synergy with a mitochondrial/cytochrome c-dependent pathway. Cancer Res. 57, 3697-3707, (1997) abstract

Kim, M.S., et al., Inhibition of histone deacetylase increases cytotoxicity to anticancer drugs targeting DNA. Cancer Res. 63, 7291-7300, (2003) abstract

Sowa, R., et al., Histone deacetylase inhibitor activates the WAF1/Cip1 gene promoter through the Sp1 sites. Biochem. Biophys. Res. Commun. 241, 142-150, (1997) abstract

Minucci, S., et al., A histone deacetylase inhibitor potentiates retinoid receptor action in embryonal carcinoma cells. Proc. Natl. Acad. Sci. USA 94, 11295-11300, (1997) abstract

3

MI5215000

T1952, Trichostatin A, Ready Made Solution