T8902
Sigma

Thiostrepton from Streptomyces azureus

≥90% (HPLC)

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Molecular Formula

C₇₂H₈₅N₁₉O₁₈S₅

Molecular Weight

1664.89

CAS Number

1393-48-2

MDL number

MFCD00135828

PubChem Substance ID

24900569

EG/EC Number

215-734-9

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Descriptions

Biochem/physiol Actions

Peptide antibiotic that prevents the binding of elongation factor G (EF-G) and GTP to the 50S ribosomal subunit.

Properties

assay

≥90% (HPLC)

storage temp.

−20°C

References

Reference

Chiu, M.L., et al., Broad spectrum thiopeptide recognition specificity of the Streptomyces lividans TipAL protein and its role in regulating gene expression. J. Biol. Chem. 274, 20578-20586, (1999) abstract

Rodnina, M.V., et al., Thiostrepton inhibits the turnover but not the GTPase of elongation factor G on the ribosome. Proc. Natl. Acad. Sci. USA 96, 9586-9590, (1999) abstract

Wimberly, B.T., et al., A detailed view of a ribosomal active site: the structure of the L11-RNA complex. Cell 97, 491-502, (1999) abstract

Merck

Merck 13,9440

Safety

Safety Statements

22-24/25

WGK Germany

RTECS

XN6300100

10-21

Related Categories

... Antibiotics A to Z > Antibiotics T-Z

... Antibiotics by Application > Genetic Marker Selection

... Mechanism of Action > Interferes with Protein Synthesis

... Antibacterial > L - Z

... Chemical Structure Class > Peptides

... Gene Regulation and Expression > RNA-Protein Translation Inhibitors

MSDS

Specification Sheet

Certificate of Analysis

Certificate of Origin

More Information